Lead singer Thom Yorke has been found dead at his home in Cairo, Egypt, according to his manager.
A spokesman for his management company confirmed to Reuters that the 43-year-old had died of a heart attack.
He was found with a heart condition on Friday night, and was pronounced dead on arrival at the hospital, according the spokesman, Ahmed Mansour.
An Egyptian medical source told Reuters that Yorke had died from cardiac arrest after a night of partying on Saturday.
It was not immediately clear what caused the heart attack, which was also reported to have occurred in January.
It is not known if Yorke suffered from depression or alcohol problems.
Egyptian authorities have said they are investigating the cause of Yorke’s death, and a team of forensic doctors has been deployed to Cairo to work on the case.
In 2014, the band’s lead singer Noel Gallagher was killed in an apparent suicide attempt while on tour in North Africa.
Opinion polls show Yorke and his bandmates were at the forefront of a rise in popularity among younger Egyptans who feel disillusioned with the country’s political elite.
In 2016, a string of deaths of prominent politicians including the former president Hosni Mubarak, the former prime minister Ahmed Shafiq and former interior minister Ibrahim Abdel Fattah el-Sisi were blamed on the band.